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| - | [[Image:1r88.jpg|left|200px]] | + | {{Seed}} |
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| | {{STRUCTURE_1r88| PDB=1r88 | SCENE= }} | | {{STRUCTURE_1r88| PDB=1r88 | SCENE= }} |
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| - | '''The crystal structure of Mycobacterium tuberculosis MPT51 (FbpC1)'''
| + | ===The crystal structure of Mycobacterium tuberculosis MPT51 (FbpC1)=== |
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| - | ==Overview==
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| - | Mycobacterium tuberculosis, the causative agent of tuberculosis, is known to secrete a number of highly immunogenic proteins that are thought to confer pathogenicity, in part, by mediating binding to host tissues. Among these secreted proteins are the trimeric antigen 85 (Ag85) complex and the related MPT51 protein, also known as FbpC1. While the physiological function of Ag85, a mycolyltransferase required for the biosynthesis of the cell wall component alpha,alpha'-trehalose dimycolate (or cord factor), has been identified recently, the function of the closely related MPT51 (approximately 40% identity with the Ag85 components) remains to be established. The crystal structure of M.tuberculosis MPT51, determined to 1.7 A resolution, shows that MPT51, like the Ag85 components Ag85B and Ag85C2, folds as an alpha/beta hydrolase, but it does not contain any of the catalytic elements required for mycolyltransferase activity. Moreover, the absence of a recognizable alpha,alpha'-trehalose monomycolate-binding site and the failure to detect an active site suggest that the function of MPT51 is of a non-enzymatic nature and that MPT51 may in fact represent a new family of non-catalytic alpha/beta hydrolases. Previous experimental evidence and the structural similarity to some integrins and carbohydrate-binding proteins led to the hypothesis that MPT51 might have a role in host tissue attachment, whereby ligands may include the serum protein fibronectin and small sugars.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_14672660}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 14672660 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_14672660}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Mpt51]] | | [[Category: Mpt51]] |
| | [[Category: Mycobacterium tuberculosis]] | | [[Category: Mycobacterium tuberculosis]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:12:21 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:51:56 2008'' |
Revision as of 01:52, 28 July 2008
Template:STRUCTURE 1r88
The crystal structure of Mycobacterium tuberculosis MPT51 (FbpC1)
Template:ABSTRACT PUBMED 14672660
About this Structure
1R88 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases., Wilson RA, Maughan WN, Kremer L, Besra GS, Futterer K, J Mol Biol. 2004 Jan 9;335(2):519-30. PMID:14672660
Page seeded by OCA on Mon Jul 28 04:51:56 2008
