1ona

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{{STRUCTURE_1ona| PDB=1ona | SCENE= }}
{{STRUCTURE_1ona| PDB=1ona | SCENE= }}
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'''CO-CRYSTALS OF CONCANAVALIN A WITH METHYL-3,6-DI-O-(ALPHA-D-MANNOPYRANOSYL)-ALPHA-D-MANNOPYRANOSIDE'''
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===CO-CRYSTALS OF CONCANAVALIN A WITH METHYL-3,6-DI-O-(ALPHA-D-MANNOPYRANOSYL)-ALPHA-D-MANNOPYRANOSIDE===
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==Overview==
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The structure of concanavalin A in complex with the trimannoside methyl-3,6-di-O-(alpha-D-mannopyranosyl)-alpha-D-mannopyranoside has been determined in a novel space group. In three of the four subunits of the concanavalin A tetramer, the interactions between the protein and the bound saccharide are essentially identical to those reported previously by other authors (Naismith, J. H., and Field, R. A. (1996) J. Biol. Chem. 271, 972-976). In the fourth subunit, however, the alpha1--&gt;3 linkage has a different conformation, resulting in a different part of the alpha1--&gt;3-linked mannose interacting with essentially the same surface of the protein. Furthermore, significant differences are observed in the quaternary associations of the subunits compared with the saccharide-free structures and other carbohydrate complexes, suggesting that the concanavalin A tetramer is a rather flexible entity.
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(as it appears on PubMed at http://www.pubmed.gov), where 8940035 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8940035}}
==About this Structure==
==About this Structure==
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[[Category: Plant lectin]]
[[Category: Plant lectin]]
[[Category: Signal]]
[[Category: Signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:57:28 2008''

Revision as of 01:57, 28 July 2008

Image:1ona.png

Template:STRUCTURE 1ona

CO-CRYSTALS OF CONCANAVALIN A WITH METHYL-3,6-DI-O-(ALPHA-D-MANNOPYRANOSYL)-ALPHA-D-MANNOPYRANOSIDE

Template:ABSTRACT PUBMED 8940035

About this Structure

1ONA is a Single protein structure of sequence from Canavalia ensiformis. Full crystallographic information is available from OCA.

Reference

A structure of the complex between concanavalin A and methyl-3,6-di-O-(alpha-D-mannopyranosyl)-alpha-D-mannopyranoside reveals two binding modes., Loris R, Maes D, Poortmans F, Wyns L, Bouckaert J, J Biol Chem. 1996 Nov 29;271(48):30614-8. PMID:8940035

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