1p9o

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[[Image:1p9o.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1p9o| PDB=1p9o | SCENE= }}
{{STRUCTURE_1p9o| PDB=1p9o | SCENE= }}
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'''Crystal Structure of Phosphopantothenoylcysteine Synthetase'''
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===Crystal Structure of Phosphopantothenoylcysteine Synthetase===
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==Overview==
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The structure of human phosphopantothenoylcysteine (PPC) synthetase was determined at 2.3 A resolution. PPC synthetase is a dimer with identical monomers. Some features of the monomer fold resemble a group of NAD-dependent enzymes, while other features resemble the ribokinase fold. The ATP, phosphopantothenate, and cysteine binding sites were deduced from modeling studies. Highly conserved ATP binding residues include Gly43, Ser61, Gly63, Gly66, Phe230, and Asn258. Highly conserved phosphopantothenate binding residues include Asn59, Ala179, Ala180, and Asp183 from one monomer and Arg55' from the adjacent monomer. The structure predicts a ping pong mechanism with initial formation of an acyladenylate intermediate, followed by release of pyrophosphate and attack by cysteine to form the final products PPC and AMP.
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(as it appears on PubMed at http://www.pubmed.gov), where 12906824 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12906824}}
==About this Structure==
==About this Structure==
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[[Category: Strauss, E.]]
[[Category: Strauss, E.]]
[[Category: Synthetase]]
[[Category: Synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:51:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:58:15 2008''

Revision as of 01:58, 28 July 2008

Image:1p9o.png

Template:STRUCTURE 1p9o

Crystal Structure of Phosphopantothenoylcysteine Synthetase

Template:ABSTRACT PUBMED 12906824

About this Structure

1P9O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution., Manoj N, Strauss E, Begley TP, Ealick SE, Structure. 2003 Aug;11(8):927-36. PMID:12906824

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