2bp6

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{{STRUCTURE_2bp6| PDB=2bp6 | SCENE= }}
{{STRUCTURE_2bp6| PDB=2bp6 | SCENE= }}
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'''CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH A-L-GALACTOPYRANOSIDE'''
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===CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH A-L-GALACTOPYRANOSIDE===
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==Overview==
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The lectin from Pseudomonas aeruginosa (PA-IIL) is involved in host recognition and biofilm formation. Lectin not only displays an unusually high affinity for fucose but also binds to L-fucose, L-galactose and D-arabinose that differ only by the group at position 5 of the sugar ring. Isothermal calorimetry experiments provided precise determination of affinity for the three methyl-glycosides and revealed a large enthalpy contribution. The crystal structures of the complexes of PA-IIL with L-galactose and Met-beta-D-arabinoside have been determined and compared with the PA-IIL/fucose complex described previously. A combination of the structures and thermodynamics provided clues for the role of the hydrophobic group in affinity.
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(as it appears on PubMed at http://www.pubmed.gov), where 16438968 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16438968}}
==About this Structure==
==About this Structure==
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[[Category: Wimmerova, M.]]
[[Category: Wimmerova, M.]]
[[Category: Lectin,galactose,calcium,pseudomonas aeruginosa]]
[[Category: Lectin,galactose,calcium,pseudomonas aeruginosa]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:36:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:01:19 2008''

Revision as of 02:01, 28 July 2008

Image:2bp6.png

Template:STRUCTURE 2bp6

CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA LECTIN (PA-IIL) COMPLEXED WITH A-L-GALACTOPYRANOSIDE

Template:ABSTRACT PUBMED 16438968

About this Structure

2BP6 is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Binding of different monosaccharides by lectin PA-IIL from Pseudomonas aeruginosa: thermodynamics data correlated with X-ray structures., Sabin C, Mitchell EP, Pokorna M, Gautier C, Utille JP, Wimmerova M, Imberty A, FEBS Lett. 2006 Feb 6;580(3):982-7. Epub 2006 Jan 19. PMID:16438968

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