2hwn

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{{STRUCTURE_2hwn| PDB=2hwn | SCENE= }}
{{STRUCTURE_2hwn| PDB=2hwn | SCENE= }}
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'''Crystal Structure of RII alpha Dimerization/Docking domain of PKA bound to the D-AKAP2 peptide'''
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===Crystal Structure of RII alpha Dimerization/Docking domain of PKA bound to the D-AKAP2 peptide===
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==Overview==
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A kinase-anchoring proteins (AKAPs) target PKA to specific microdomains by using an amphipathic helix that docks to N-terminal dimerization and docking (D/D) domains of PKA regulatory (R) subunits. To understand specificity, we solved the crystal structure of the helical motif from D-AKAP2, a dual-specific AKAP, bound to the RIIalpha D/D domain. The 1.6 Angstrom structure reveals how this dynamic, hydrophobic docking site is assembled. A stable, hydrophobic docking groove is formed by the helical interface of two RIIalpha protomers. The flexible N terminus of one protomer is then recruited to the site, anchored to the peptide through two essential isoleucines. The other N terminus is disordered. This asymmetry provides greater possibilities for AKAP docking. Although there is strong discrimination against RIalpha in the N terminus of the AKAP helix, the hydrophobic groove discriminates against RIIalpha. RIalpha, with a cavity in the groove, can accept a bulky tryptophan, whereas RIIalpha requires valine.
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(as it appears on PubMed at http://www.pubmed.gov), where 17081990 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17081990}}
==About this Structure==
==About this Structure==
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[[Category: Pka]]
[[Category: Pka]]
[[Category: Regulatory subunit]]
[[Category: Regulatory subunit]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:48:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:05:03 2008''

Revision as of 02:05, 28 July 2008

Image:2hwn.png

Template:STRUCTURE 2hwn

Crystal Structure of RII alpha Dimerization/Docking domain of PKA bound to the D-AKAP2 peptide

Template:ABSTRACT PUBMED 17081990

About this Structure

2HWN is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase., Kinderman FS, Kim C, von Daake S, Ma Y, Pham BQ, Spraggon G, Xuong NH, Jennings PA, Taylor SS, Mol Cell. 2006 Nov 3;24(3):397-408. PMID:17081990

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