2fp3

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{{STRUCTURE_2fp3| PDB=2fp3 | SCENE= }}
{{STRUCTURE_2fp3| PDB=2fp3 | SCENE= }}
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'''Crystal structure of the Drosophila initiator caspase Dronc'''
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===Crystal structure of the Drosophila initiator caspase Dronc===
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==Overview==
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Activation of an initiator caspase is essential to the execution of apoptosis. The molecular mechanisms by which initiator caspases are activated remain poorly understood. Here we demonstrate that the autocatalytic cleavage of Dronc, an important initiator caspase in Drosophila, results in a drastic enhancement of its catalytic activity in vitro. The autocleaved Dronc forms a homodimer, whereas the uncleaved Dronc zymogen exists exclusively as a monomer. Thus the autocatalytic cleavage in Dronc induces its stable dimerization, which presumably allows the two adjacent monomers to mutually stabilize their active sites, leading to activation. Crystal structure of a prodomain-deleted Dronc zymogen, determined at 2.5 A resolution, reveals an unproductive conformation at the active site, which is consistent with the observation that the zymogen remains catalytically inactive. This study revealed insights into mechanism of Dronc activation, and in conjunction with other observations, suggests diverse mechanisms for the activation of initiator caspases.
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(as it appears on PubMed at http://www.pubmed.gov), where 16446367 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16446367}}
==About this Structure==
==About this Structure==
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[[Category: Dimerization]]
[[Category: Dimerization]]
[[Category: Initiator caspase activation]]
[[Category: Initiator caspase activation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:09:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:04:59 2008''

Revision as of 02:05, 28 July 2008

Image:2fp3.png

Template:STRUCTURE 2fp3

Crystal structure of the Drosophila initiator caspase Dronc

Template:ABSTRACT PUBMED 16446367

About this Structure

2FP3 is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structure and activation mechanism of the Drosophila initiator caspase Dronc., Yan N, Huh JR, Schirf V, Demeler B, Hay BA, Shi Y, J Biol Chem. 2006 Mar 31;281(13):8667-74. Epub 2006 Jan 30. PMID:16446367

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