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1tk7

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{{STRUCTURE_1tk7| PDB=1tk7 | SCENE= }}
{{STRUCTURE_1tk7| PDB=1tk7 | SCENE= }}
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'''NMR structure of WW domains (WW3-4) from Suppressor of Deltex'''
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===NMR structure of WW domains (WW3-4) from Suppressor of Deltex===
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==Overview==
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WW domains mediate protein recognition, usually though binding to proline-rich sequences. In many proteins, WW domains occur in tandem arrays. Whether or how individual domains within such arrays cooperate to recognize biological partners is, as yet, poorly characterized. An important question is whether functional diversity of different WW domain proteins is reflected in the structural organization and ligand interaction mechanisms of their multiple domains. We have determined the solution structure and dynamics of a pair of WW domains (WW3-4) from a Drosophila Nedd4 family protein called Suppressor of deltex (Su(dx)), a regulator of Notch receptor signaling. We find that the binding of a type 1 PPPY ligand to WW3 stabilizes the structure with effects propagating to the WW4 domain, a domain that is not active for ligand binding. Both WW domains adopt the characteristic triple-stranded beta-sheet structure, and significantly, this is the first example of a WW domain structure to include a domain (WW4) lacking the second conserved Trp (replaced by Phe). The domains are connected by a flexible linker, which allows a hinge-like motion of domains that may be important for the recognition of functionally relevant targets. Our results contrast markedly with those of the only previously determined three-dimensional structure of tandem WW domains, that of the rigidly oriented WW domain pair from the RNA-splicing factor Prp40. Our data illustrate that arrays of WW domains can exhibit a variety of higher order structures and ligand interaction mechanisms.
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{{ABSTRACT_PUBMED_15173166}}
==About this Structure==
==About this Structure==
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1TK7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK7 OCA].
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1TK7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TK7 OCA].
==Reference==
==Reference==
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[[Category: Notch]]
[[Category: Notch]]
[[Category: Ww domain]]
[[Category: Ww domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:03:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:06:15 2008''

Revision as of 02:06, 28 July 2008

Image:1tk7.png

Template:STRUCTURE 1tk7

NMR structure of WW domains (WW3-4) from Suppressor of Deltex

Template:ABSTRACT PUBMED 15173166

About this Structure

1TK7 is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

The structure and dynamics of tandem WW domains in a negative regulator of notch signaling, Suppressor of deltex., Fedoroff OY, Townson SA, Golovanov AP, Baron M, Avis JM, J Biol Chem. 2004 Aug 13;279(33):34991-5000. Epub 2004 Jun 1. PMID:15173166

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