1qx6

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{{STRUCTURE_1qx6| PDB=1qx6 | SCENE= }}
{{STRUCTURE_1qx6| PDB=1qx6 | SCENE= }}
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'''Crystal structure of Sortase B complexed with E-64'''
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===Crystal structure of Sortase B complexed with E-64===
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==Overview==
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Many surface proteins of Gram-positive bacteria, which play important roles during the pathogenesis of human infections, are anchored to the cell wall envelope by a mechanism requiring sortases. Sortase B, a cysteine transpeptidase from Staphylococcus aureus, cleaves the C-terminal sorting signal of IsdC at the NPQTN motif and tethers the polypeptide to the pentaglycine cell wall cross-bridge. During catalysis, the active site cysteine of sortase and the cleaved substrate form an acyl intermediate, which is then resolved by the amino group of pentaglycine cross-bridges. We report here the crystal structures of SrtBDeltaN30 in complex with two active site inhibitors, MTSET and E64, and with the cell wall substrate analog tripleglycine. These structures reveal, for the first time, the active site disposition and the unique Cys-Arg catalytic machinery of the cysteine transpeptidase, and they also provide useful information for the future design of anti-infective agents against sortases.
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(as it appears on PubMed at http://www.pubmed.gov), where 14725770 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14725770}}
==About this Structure==
==About this Structure==
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[[Category: Sortase]]
[[Category: Sortase]]
[[Category: Transpeptidase]]
[[Category: Transpeptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:48:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:10:18 2008''

Revision as of 02:10, 28 July 2008

Image:1qx6.png

Template:STRUCTURE 1qx6

Crystal structure of Sortase B complexed with E-64

Template:ABSTRACT PUBMED 14725770

About this Structure

1QX6 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall., Zong Y, Mazmanian SK, Schneewind O, Narayana SV, Structure. 2004 Jan;12(1):105-12. PMID:14725770

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