2peq

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{{STRUCTURE_2peq| PDB=2peq | SCENE= }}
{{STRUCTURE_2peq| PDB=2peq | SCENE= }}
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'''Crystal structure of RbcX, crystal form II'''
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===Crystal structure of RbcX, crystal form II===
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==Overview==
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After folding, many proteins must assemble into oligomeric complexes to become biologically active. Here we describe the role of RbcX as an assembly chaperone of ribulose-bisphosphate carboxylase/oxygenase (Rubisco), the enzyme responsible for the fixation of atmospheric carbon dioxide. In cyanobacteria and plants, Rubisco is an approximately 520 kDa complex composed of eight large subunits (RbcL) and eight small subunits (RbcS). We found that cyanobacterial RbcX functions downstream of chaperonin-mediated RbcL folding in promoting the formation of RbcL(8) core complexes. Structural analysis revealed that the 15 kDa RbcX forms a homodimer with two cooperating RbcL-binding regions. A central cleft specifically binds the exposed C-terminal peptide of RbcL subunits, enabling a peripheral surface of RbcX to mediate RbcL(8) assembly. Due to the dynamic nature of these interactions, RbcX is readily displaced from RbcL(8) complexes by RbcS, producing the active enzyme. The strategies employed by RbcX in achieving substrate specificity and efficient product release may be generally relevant in assisted assembly reactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 17574029 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17574029}}
==About this Structure==
==About this Structure==
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[[Category: Helix bundle]]
[[Category: Helix bundle]]
[[Category: Protein complex assembly]]
[[Category: Protein complex assembly]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:58:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:13:01 2008''

Revision as of 02:13, 28 July 2008

Image:2peq.png

Template:STRUCTURE 2peq

Crystal structure of RbcX, crystal form II

Template:ABSTRACT PUBMED 17574029

About this Structure

2PEQ is a Single protein structure of sequence from Synechococcus sp. pcc 7002. Full crystallographic information is available from OCA.

Reference

Structure and function of RbcX, an assembly chaperone for hexadecameric Rubisco., Saschenbrecker S, Bracher A, Rao KV, Rao BV, Hartl FU, Hayer-Hartl M, Cell. 2007 Jun 15;129(6):1189-200. PMID:17574029

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