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| - | [[Image:1ncz.gif|left|200px]] | + | {{Seed}} |
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| | {{STRUCTURE_1ncz| PDB=1ncz | SCENE= }} | | {{STRUCTURE_1ncz| PDB=1ncz | SCENE= }} |
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| - | '''TROPONIN C'''
| + | ===TROPONIN C=== |
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| - | ==Overview==
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| - | The crystal structures of three metal complexes of troponin C (TnC) have been determined and refined where the two occupied structural Ca(2+) sites in the C domain have been substituted by Mn(2+), Cd(2+) and Tb(3+). The X-ray intensity data were collected to 2.1, 1.8 and 1.8 A resolution, respectively, on the three metal complexes, which are isomorphous with Ca-TnC. The three complexes have r.m.s. deviations of 0.27, 0.25 and 0.35 A, respectively, for all protein atoms, from Ca-TnC. Irrespective of the charge on the metal (+2 or +3), the occupied sites 3 and 4 exhibit a distorted pentagonal bipyramidal coordination, like Ca-TnC, with seven ligands, six from the 12-residue binding loop and the seventh from a water molecule. Mn(2+) at site 4 seems to display a longer distance to one of the carboxyl bidentate ligands representing an intermediate coordination simulating the six-coordinate Mg(2+). The carboxyl O atoms of the bidentate Glu12 are displaced on the side of the equatorial plane passing through the remaining three ligands with one O atom closer to the plane (Delta of 0.11 to 0.76 A) than the other (Delta of 0.93 to 1.38 A). The two axial ligands are an aspartic carboxyl O atom and a water molecule. The metal is displaced (0.18 to 0.56 A) towards the water facing the water channel.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_15299599}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 15299599 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_15299599}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Duplication]] | | [[Category: Duplication]] |
| | [[Category: Muscle protein]] | | [[Category: Muscle protein]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:23:03 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:15:11 2008'' |
Revision as of 02:15, 28 July 2008
Template:STRUCTURE 1ncz
TROPONIN C
Template:ABSTRACT PUBMED 15299599
About this Structure
1NCZ is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.
Reference
X-ray structures of Mn, Cd and Tb metal complexes of troponin C., Rao ST, Satyshur KA, Greaser ML, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 1996 Sep 1;52(Pt 5):916-22. PMID:15299599
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