1uoc

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{{STRUCTURE_1uoc| PDB=1uoc | SCENE= }}
{{STRUCTURE_1uoc| PDB=1uoc | SCENE= }}
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'''X-RAY STRUCTURE OF THE RNASE DOMAIN OF THE YEAST POP2 PROTEIN'''
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===X-RAY STRUCTURE OF THE RNASE DOMAIN OF THE YEAST POP2 PROTEIN===
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==Overview==
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In Saccharomyces cerevisiae, a large complex, known as the Ccr4-Not complex, containing two nucleases, is responsible for mRNA deadenylation. One of these nucleases is called Pop2 and has been identified by similarity with PARN, a human poly(A) nuclease. Here, we present the crystal structure of the nuclease domain of Pop2 at 2.3 A resolution. The domain has the fold of the DnaQ family and represents the first structure of an RNase from the DEDD superfamily. Despite the presence of two non-canonical residues in the active site, the domain displays RNase activity on a broad range of RNA substrates. Site-directed mutagenesis of active-site residues demonstrates the intrinsic ability of the Pop2 RNase D domain to digest RNA. This first structure of a nuclease involved in the 3'-5' deadenylation of mRNA in yeast provides information for the understanding of the mechanism by which the Ccr4-Not complex achieves its functions.
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(as it appears on PubMed at http://www.pubmed.gov), where 14618157 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14618157}}
==About this Structure==
==About this Structure==
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[[Category: Repressor]]
[[Category: Repressor]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:29:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:18:29 2008''

Revision as of 02:18, 28 July 2008

Image:1uoc.png

Template:STRUCTURE 1uoc

X-RAY STRUCTURE OF THE RNASE DOMAIN OF THE YEAST POP2 PROTEIN

Template:ABSTRACT PUBMED 14618157

About this Structure

1UOC is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

X-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complex., Thore S, Mauxion F, Seraphin B, Suck D, EMBO Rep. 2003 Dec;4(12):1150-5. Epub 2003 Nov 14. PMID:14618157

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