1sxd

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[[Image:1sxd.gif|left|200px]]
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{{STRUCTURE_1sxd| PDB=1sxd | SCENE= }}
{{STRUCTURE_1sxd| PDB=1sxd | SCENE= }}
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'''Solution Structure of the Pointed (PNT) Domain from mGABPa'''
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===Solution Structure of the Pointed (PNT) Domain from mGABPa===
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==Overview==
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The PNT (or Pointed) domain, present within a subset of the Ets family of transcription factors, is structurally related to the larger group of SAM domains through a common tertiary arrangement of four alpha-helices. Previous studies have shown that, in contrast to the PNT domain from Tel, this domain from Ets-1 contains an additional N-terminal helix integral to its folded structure. To further investigate the structural plasticity of the PNT domain, we have used NMR spectroscopy to characterize this domain from two additional Ets proteins, Erg and GABPalpha. These studies both define the conserved and variable features of the PNT domain, and demonstrate that the additional N-terminal helix is also present in GABPalpha, but not Erg. In contrast to Tel and Yan, which self-associate to form insoluble polymers, we also show that the isolated PNT domains from Ets-1, Ets-2, Erg, Fli-1, GABPalpha, and Pnt-P2 are monomeric in solution. Furthermore, these soluble PNT domains do not associate in any pair-wise combination. Thus these latter Ets family PNT domains likely mediate interactions with additional components of the cellular signaling or transcriptional machinery.
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{{ABSTRACT_PUBMED_15351649}}
==About this Structure==
==About this Structure==
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1SXD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SXD OCA].
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1SXD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SXD OCA].
==Reference==
==Reference==
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[[Category: Slupsky, C M.]]
[[Category: Slupsky, C M.]]
[[Category: Alpha helical]]
[[Category: Alpha helical]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:14:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:22:44 2008''

Revision as of 02:22, 28 July 2008

Image:1sxd.png

Template:STRUCTURE 1sxd

Solution Structure of the Pointed (PNT) Domain from mGABPa

Template:ABSTRACT PUBMED 15351649

About this Structure

1SXD is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Diversity in structure and function of the Ets family PNT domains., Mackereth CD, Scharpf M, Gentile LN, MacIntosh SE, Slupsky CM, McIntosh LP, J Mol Biol. 2004 Sep 24;342(4):1249-64. PMID:15351649

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