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2rak

From Proteopedia

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{{STRUCTURE_2rak| PDB=2rak | SCENE= }}
{{STRUCTURE_2rak| PDB=2rak | SCENE= }}
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'''PI(3)P bound PX-BAR membrane remodeling unit of Sorting Nexin 9'''
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===PI(3)P bound PX-BAR membrane remodeling unit of Sorting Nexin 9===
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==Overview==
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Sorting nexins (SNXs) form a family of proteins known to interact with components in the endosomal system and to regulate various steps of vesicle transport. Sorting nexin 9 (SNX9) is involved in the late stages of clathrin-mediated endocytosis in non-neuronal cells, where together with the GTPase dynamin, it participates in the formation and scission of the vesicle neck. We report here crystal structures of the functional membrane-remodeling unit of SNX9 and show that it efficiently tubulates lipid membranes in vivo and in vitro. Elucidation of the protein superdomain structure, together with mutational analysis and biochemical and cell biological experiments, demonstrated how the SNX9 PX and BAR domains work in concert in targeting and tubulation of phosphoinositide-containing membranes. The study provides insights into the SNX9-induced membrane modulation mechanism.
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{{ABSTRACT_PUBMED_17948057}}
==About this Structure==
==About this Structure==
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[[Category: Structural protein]]
[[Category: Structural protein]]
[[Category: Tubulation]]
[[Category: Tubulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:33:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:24:10 2008''

Revision as of 02:24, 28 July 2008

Image:2rak.png

Template:STRUCTURE 2rak

PI(3)P bound PX-BAR membrane remodeling unit of Sorting Nexin 9

Template:ABSTRACT PUBMED 17948057

About this Structure

2RAK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The PX-BAR membrane-remodeling unit of sorting nexin 9., Pylypenko O, Lundmark R, Rasmuson E, Carlsson SR, Rak A, EMBO J. 2007 Nov 14;26(22):4788-800. Epub 2007 Oct 18. PMID:17948057

Page seeded by OCA on Mon Jul 28 05:24:10 2008

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