2cie

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{{STRUCTURE_2cie| PDB=2cie | SCENE= }}
{{STRUCTURE_2cie| PDB=2cie | SCENE= }}
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'''COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS'''
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===COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS===
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==Overview==
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Both extensive theoretical calculations and experimental data obtained during several decades leave little doubt that flavin adenine dinucleotide (FAD) exists in an open as well as in a closed conformation in aqueous solution. However, the knowledge about the intramolecularly stacked complex of FAD is constructed on indirect methods while direct structural evidence is lacking. Recently, dodecin was reported as an unspecific flavin binding protein which exhibits the unique binding mode of incorporating stacked dimers of flavins into a single binding pocket. Here, we show that FAD is not bound in this manner, but in monomers of intramolecularly stacked conformation. As resulting from the dodecin ligand binding characteristic, this FAD stacked conformation suggests to be directly sequestered from the aqueous solution and thus to be the first X-ray structural view on a FAD solution-stacked form. Moreover, in extraordinary FAD binding, dodecin serves as a model for studying bound monomeric (FAD) versus bound dimeric (e.g. riboflavin) flavin properties.
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(as it appears on PubMed at http://www.pubmed.gov), where 17027852 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17027852}}
==About this Structure==
==About this Structure==
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[[Category: Zeth, K.]]
[[Category: Zeth, K.]]
[[Category: Flavoprotein]]
[[Category: Flavoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:13:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:27:10 2008''

Revision as of 02:27, 28 July 2008

Image:2cie.png

Template:STRUCTURE 2cie

COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS

Template:ABSTRACT PUBMED 17027852

About this Structure

2CIE is a Single protein structure of sequence from Halobacterium salinarum. Full crystallographic information is available from OCA.

Reference

Dodecin sequesters FAD in closed conformation from the aqueous solution., Grininger M, Seiler F, Zeth K, Oesterhelt D, J Mol Biol. 2006 Dec 8;364(4):561-6. Epub 2006 Sep 5. PMID:17027852

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