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1t0p

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{{STRUCTURE_1t0p| PDB=1t0p | SCENE= }}
{{STRUCTURE_1t0p| PDB=1t0p | SCENE= }}
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'''Structural Basis of ICAM recognition by integrin alpahLbeta2 revealed in the complex structure of binding domains of ICAM-3 and alphaLbeta2 at 1.65 A'''
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===Structural Basis of ICAM recognition by integrin alpahLbeta2 revealed in the complex structure of binding domains of ICAM-3 and alphaLbeta2 at 1.65 A===
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==Overview==
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Within the Ig superfamily (IgSF), intercellular adhesion molecules (ICAMs) form a subfamily that binds the leukocyte integrin alphaLbeta2. We report a 1.65-A-resolution crystal structure of the ICAM-3 N-terminal domain (D1) in complex with the inserted domain, the ligand-binding domain of alphaLbeta2. This high-resolution structure and comparisons among ICAM subfamily members establish that the binding of ICAM-3 D1 onto the inserted domain represents a common docking mode for ICAM subfamily members. The markedly different off-rates of ICAM-1, -2, and -3 appear to be determined by the hydrophobicity of residues that surround a metal coordination bond in the alphaLbeta2-binding interfaces. Variation in composition of glycans on the periphery of the interfaces influences on-rate.
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(as it appears on PubMed at http://www.pubmed.gov), where 15728350 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15728350}}
==About this Structure==
==About this Structure==
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[[Category: Ig-super family domain]]
[[Category: Ig-super family domain]]
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:21:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:27:41 2008''

Revision as of 02:27, 28 July 2008

Image:1t0p.png

Template:STRUCTURE 1t0p

Structural Basis of ICAM recognition by integrin alpahLbeta2 revealed in the complex structure of binding domains of ICAM-3 and alphaLbeta2 at 1.65 A

Template:ABSTRACT PUBMED 15728350

About this Structure

1T0P is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2., Song G, Yang Y, Liu JH, Casasnovas JM, Shimaoka M, Springer TA, Wang JH, Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3366-71. Epub 2005 Feb 22. PMID:15728350

Page seeded by OCA on Mon Jul 28 05:27:41 2008

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