2p63

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{{STRUCTURE_2p63| PDB=2p63 | SCENE= }}
{{STRUCTURE_2p63| PDB=2p63 | SCENE= }}
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'''Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination'''
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===Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination===
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==Overview==
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SCF ubiquitin ligases recruit substrates for degradation via F box protein adaptor subunits. WD40 repeat F box proteins, such as Cdc4 and beta-TrCP, contain a conserved dimerization motif called the D domain. Here, we report that the D domain protomers of yeast Cdc4 and human beta-TrCP form a superhelical homotypic dimer. Disruption of the D domain compromises the activity of yeast SCF(Cdc4) toward the CDK inhibitor Sic1 and other substrates. SCF(Cdc4) dimerization has little effect on the affinity for Sic1 but markedly stimulates ubiquitin conjugation. A model of the dimeric holo-SCF(Cdc4) complex based on small-angle X-ray scatter measurements reveals a suprafacial configuration, in which substrate-binding sites and E2 catalytic sites lie in the same plane with a separation of 64 A within and 102 A between each SCF monomer. This spatial variability may accommodate diverse acceptor lysine geometries in both substrates and the elongating ubiquitin chain and thereby increase catalytic efficiency.
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{{ABSTRACT_PUBMED_17574027}}
==About this Structure==
==About this Structure==
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[[Category: Scf complex]]
[[Category: Scf complex]]
[[Category: Ubiquitination]]
[[Category: Ubiquitination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 18 12:17:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:29:39 2008''

Revision as of 02:29, 28 July 2008

Image:2p63.png

Template:STRUCTURE 2p63

Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination

Template:ABSTRACT PUBMED 17574027

About this Structure

2P63 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination., Tang X, Orlicky S, Lin Z, Willems A, Neculai D, Ceccarelli D, Mercurio F, Shilton BH, Sicheri F, Tyers M, Cell. 2007 Jun 15;129(6):1165-76. PMID:17574027

Page seeded by OCA on Mon Jul 28 05:29:39 2008

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