2pdz

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{{STRUCTURE_2pdz| PDB=2pdz | SCENE= }}
{{STRUCTURE_2pdz| PDB=2pdz | SCENE= }}
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'''SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOMAIN IN COMPLEX WITH THE PEPTIDE GVKESLV, NMR, 15 STRUCTURES'''
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===SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOMAIN IN COMPLEX WITH THE PEPTIDE GVKESLV, NMR, 15 STRUCTURES===
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==Overview==
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Syntrophins are modular proteins belonging to the dystrophin associated glycoprotein complex and are thought to be involved in the regulation of the muscular system. Screening of peptide libraries revealed selectivity of the synotrophin PDZ domain toward the motif R/K/Q-E-S/T-X-V-COO- found to be highly conserved in the alpha-subunit C-terminus of vertebrate voltage gated sodium channels (VGSCs). The solution structure of the domain in complex with the peptide G-V-K-E-S-L-V shows specific interactions between the conserved residues in the peptide and syntrophin-characteristic residues in the domain. We propose that syntrophins localize VGSCs to the dystrophin network through its PDZ domain.
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{{ABSTRACT_PUBMED_9437424}}
==About this Structure==
==About this Structure==
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2PDZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PDZ OCA].
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2PDZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PDZ OCA].
==Reference==
==Reference==
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[[Category: Syntrophin pdz domain]]
[[Category: Syntrophin pdz domain]]
[[Category: Voltage-gated sodium channel]]
[[Category: Voltage-gated sodium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:30:20 2008''

Revision as of 02:30, 28 July 2008

Image:2pdz.png

Template:STRUCTURE 2pdz

SOLUTION STRUCTURE OF THE SYNTROPHIN PDZ DOMAIN IN COMPLEX WITH THE PEPTIDE GVKESLV, NMR, 15 STRUCTURES

Template:ABSTRACT PUBMED 9437424

About this Structure

2PDZ is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels., Schultz J, Hoffmuller U, Krause G, Ashurst J, Macias MJ, Schmieder P, Schneider-Mergener J, Oschkinat H, Nat Struct Biol. 1998 Jan;5(1):19-24. PMID:9437424

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