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2nsu

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{{STRUCTURE_2nsu| PDB=2nsu | SCENE= }}
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'''Crystal structure of the ectodomain of human transferrin receptor fitted into a cryo-EM reconstruction of canine parvovirus and feline transferrin receptor complex'''
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===Crystal structure of the ectodomain of human transferrin receptor fitted into a cryo-EM reconstruction of canine parvovirus and feline transferrin receptor complex===
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==Overview==
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Although many viruses are icosahedral when they initially bind to one or more receptor molecules on the cell surface, such an interaction is asymmetric, probably causing a breakdown in the symmetry and conformation of the original infecting virion in preparation for membrane penetration and release of the viral genome. Cryoelectron microscopy and biochemical analyses show that transferrin receptor, the cellular receptor for canine parvovirus, can bind to only one or a few of the 60 icosahedrally equivalent sites on the virion, indicating that either canine parvovirus has inherent asymmetry or binding of receptor induces asymmetry. The asymmetry of receptor binding to canine parvovirus is reminiscent of the special portal in tailed bacteriophages and some large, icosahedral viruses. Asymmetric interactions of icosahedral viruses with their hosts might be a more common phenomenon than previously thought and may have been obscured by averaging in previous crystallographic and electron microscopic structure determinations.
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(as it appears on PubMed at http://www.pubmed.gov), where 17420467 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17420467}}
==About this Structure==
==About this Structure==
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[[Category: Transferrin receptor]]
[[Category: Transferrin receptor]]
[[Category: Virus-receptor complex]]
[[Category: Virus-receptor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:52:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:37:57 2008''

Revision as of 02:38, 28 July 2008

Image:2nsu.png

Template:STRUCTURE 2nsu

Crystal structure of the ectodomain of human transferrin receptor fitted into a cryo-EM reconstruction of canine parvovirus and feline transferrin receptor complex

Template:ABSTRACT PUBMED 17420467

About this Structure

2NSU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Asymmetric binding of transferrin receptor to parvovirus capsids., Hafenstein S, Palermo LM, Kostyuchenko VA, Xiao C, Morais MC, Nelson CD, Bowman VD, Battisti AJ, Chipman PR, Parrish CR, Rossmann MG, Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6585-9. Epub 2007 Apr 9. PMID:17420467

Page seeded by OCA on Mon Jul 28 05:37:57 2008

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