1zjr

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{{Seed}}
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{{STRUCTURE_1zjr| PDB=1zjr | SCENE= }}
{{STRUCTURE_1zjr| PDB=1zjr | SCENE= }}
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'''Crystal Structure of A. aeolicus TrmH/SpoU tRNA modifying enzyme'''
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===Crystal Structure of A. aeolicus TrmH/SpoU tRNA modifying enzyme===
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==Overview==
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Biological RNAs contain a variety of post-transcriptional modifications that facilitate their efficient function in the cellular environment. One of the two most common forms of modification is methylation of the 2'-hydroxyl group of the ribose sugar, which is performed by a number of S-adenosylmethionine (SAM) dependent methyltransferases. In bacteria, many of these modifications in tRNA and rRNA are carried out by the alpha/beta-knot superfamily of enzymes, whose SAM-binding pocket is created by a characteristic deep trefoil knot. TrmH, an enzyme found throughout all three kingdoms of life, modifies the universally conserved guanosine 18 position of tRNA. The crystal structure of TrmH from the thermophilic bacterium Aquifex aeolicus has been determined at 1.85 A resolution using data collected from a synchrotron-radiation source. The protein reveals a fold typical of members of the SpoU clan of proteins, a subfamily of the alpha/beta-knot superfamily, with alpha-helical extensions at the N- and C-termini that are likely to be involved in tRNA binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 16511140 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16511140}}
==About this Structure==
==About this Structure==
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[[Category: Rna modifying enzyme]]
[[Category: Rna modifying enzyme]]
[[Category: Topological knot]]
[[Category: Topological knot]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:42:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:42:35 2008''

Revision as of 02:42, 28 July 2008

Image:1zjr.png

Template:STRUCTURE 1zjr

Crystal Structure of A. aeolicus TrmH/SpoU tRNA modifying enzyme

Template:ABSTRACT PUBMED 16511140

About this Structure

1ZJR is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Structure of a class II TrmH tRNA-modifying enzyme from Aquifex aeolicus., Pleshe E, Truesdell J, Batey RT, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Aug 1;61(Pt, 8):722-8. Epub 2005 Jul 30. PMID:16511140

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