1t5q

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[[Image:1t5q.gif|left|200px]]
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{{Seed}}
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[[Image:1t5q.png|left|200px]]
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{{STRUCTURE_1t5q| PDB=1t5q | SCENE= }}
{{STRUCTURE_1t5q| PDB=1t5q | SCENE= }}
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'''Solution Structure of GIP(1-30)amide in TFE/Water'''
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===Solution Structure of GIP(1-30)amide in TFE/Water===
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==Overview==
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Glucose-dependent insulinotropic polypeptide is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. The glucose-dependent action of GIP on pancreatic beta-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. Use of NMR or X-ray crystallography is vital to determine the three-dimensional structure of the peptide. Therefore, to understand the basic structural requirements for the biological activity of GIP, the solution structure of the major biologically active fragment, GIP(1-30)amide, was investigated by proton NMR spectroscopy and molecular modelling. The structure is characterised by a full length alpha-helical conformation between residues F(6) and A(28). This structural information could play an important role in the design of therapeutic agents based upon GIP receptor agonists.
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The line below this paragraph, {{ABSTRACT_PUBMED_15522230}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15522230 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15522230}}
==About this Structure==
==About this Structure==
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1T5Q is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5Q OCA].
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1T5Q is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T5Q OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Obesity]]
[[Category: Obesity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:33:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:42:32 2008''

Revision as of 02:42, 28 July 2008

Image:1t5q.png

Template:STRUCTURE 1t5q

Solution Structure of GIP(1-30)amide in TFE/Water

Template:ABSTRACT PUBMED 15522230

About this Structure

1T5Q is a Single protein structure. Full experimental information is available from OCA.

Reference

NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide., Alana I, Hewage CM, Malthouse JP, Parker JC, Gault VA, O'Harte FP, Biochem Biophys Res Commun. 2004 Dec 3;325(1):281-6. PMID:15522230

Page seeded by OCA on Mon Jul 28 05:42:32 2008

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