2bdw

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{{STRUCTURE_2bdw| PDB=2bdw | SCENE= }}
{{STRUCTURE_2bdw| PDB=2bdw | SCENE= }}
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'''Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II'''
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===Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II===
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==Overview==
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Ca2+/calmodulin-dependent protein kinase-II (CaMKII) is unique among protein kinases for its dodecameric assembly and its complex response to Ca2+. The crystal structure of the autoinhibited kinase domain of CaMKII, determined at 1.8 A resolution, reveals an unexpected dimeric organization in which the calmodulin-responsive regulatory segments form a coiled-coil strut that blocks peptide and ATP binding to the otherwise intrinsically active kinase domains. A threonine residue in the regulatory segment, which when phosphorylated renders CaMKII calmodulin independent, is held apart from the catalytic sites by the organization of the dimer. This ensures a strict Ca2+ dependence for initial activation. The structure of the kinase dimer, when combined with small-angle X-ray scattering data for the holoenzyme, suggests that inactive CaMKII forms tightly packed autoinhibited assemblies that convert upon activation into clusters of loosely tethered and independent kinase domains.
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(as it appears on PubMed at http://www.pubmed.gov), where 16325579 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16325579}}
==About this Structure==
==About this Structure==
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[[Category: Calmodulin activated]]
[[Category: Calmodulin activated]]
[[Category: Kinase]]
[[Category: Kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:09:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:44:18 2008''

Revision as of 02:44, 28 July 2008

Image:2bdw.png

Template:STRUCTURE 2bdw

Crystal Structure of the Auto-Inhibited Kinase Domain of Calcium/Calmodulin Activated Kinase II

Template:ABSTRACT PUBMED 16325579

About this Structure

2BDW is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme., Rosenberg OS, Deindl S, Sung RJ, Nairn AC, Kuriyan J, Cell. 2005 Dec 2;123(5):849-60. PMID:16325579

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