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2ckz

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[[Image:2ckz.gif|left|200px]]
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{{STRUCTURE_2ckz| PDB=2ckz | SCENE= }}
{{STRUCTURE_2ckz| PDB=2ckz | SCENE= }}
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'''X-RAY STRUCTURE OF RNA POLYMERASE III SUBCOMPLEX C17-C25.'''
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===X-RAY STRUCTURE OF RNA POLYMERASE III SUBCOMPLEX C17-C25.===
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==Overview==
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We obtained an 11 subunit model of RNA polymerase (Pol) III by combining a homology model of the nine subunit core enzyme with a new X-ray structure of the subcomplex C17/25. Compared to Pol II, Pol III shows a conserved active center for RNA synthesis but a structurally different upstream face for specific initiation complex assembly during promoter selection. The Pol III upstream face includes a HRDC domain in subunit C17 that is translated by 35 A and rotated by 150 degrees compared to its Pol II counterpart. The HRDC domain is essential in vivo, folds independently in vitro, and, unlike other HRDC domains, shows no indication of nucleic acid binding. Thus, the HRDC domain is a functional module that could account for the role of C17 in Pol III promoter-specific initiation. During elongation, C17/25 may bind Pol III transcripts emerging from the adjacent exit pore, because the subcomplex binds to tRNA in vitro.
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(as it appears on PubMed at http://www.pubmed.gov), where 16818233 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16818233}}
==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Trna synthesis]]
[[Category: Trna synthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:23:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:51:32 2008''

Revision as of 02:51, 28 July 2008

Image:2ckz.png

Template:STRUCTURE 2ckz

X-RAY STRUCTURE OF RNA POLYMERASE III SUBCOMPLEX C17-C25.

Template:ABSTRACT PUBMED 16818233

About this Structure

2CKZ is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural biology of RNA polymerase III: subcomplex C17/25 X-ray structure and 11 subunit enzyme model., Jasiak AJ, Armache KJ, Martens B, Jansen RP, Cramer P, Mol Cell. 2006 Jul 7;23(1):71-81. PMID:16818233

Page seeded by OCA on Mon Jul 28 05:51:32 2008

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