1shs

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{{STRUCTURE_1shs| PDB=1shs | SCENE= }}
{{STRUCTURE_1shs| PDB=1shs | SCENE= }}
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'''SMALL HEAT SHOCK PROTEIN FROM METHANOCOCCUS JANNASCHII'''
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===SMALL HEAT SHOCK PROTEIN FROM METHANOCOCCUS JANNASCHII===
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==Overview==
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The principal heat-shock proteins that have chaperone activity (that is, they protect newly made proteins from misfolding) belong to five conserved classes: HSP100, HSP90, HSP70, HSP60 and the small heat-shock proteins (sHSPs). The sHSPs can form large multimeric structures and have a wide range of cellular functions, including endowing cells with thermotolerance in vivo and being able to act as molecular chaperones in vitro; sHSPs do this by forming stable complexes with folding intermediates of their protein substrates. However, there is little information available about these structures or the mechanism by which substrates are protected from thermal denaturation by sHSPs. Here we report the crystal structure of a small heat-shock protein from Methanococcus jannaschii, a hyperthermophilic archaeon. The monomeric folding unit is a composite beta-sandwich in which one of the beta-strands comes from a neighbouring molecule. Twenty-four monomers form a hollow spherical complex of octahedral symmetry, with eight trigonal and six square 'windows'. The sphere has an outer diameter of 120 A and an inner diameter of 65 A.
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{{ABSTRACT_PUBMED_9707123}}
==About this Structure==
==About this Structure==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:52:09 2008''

Revision as of 02:52, 28 July 2008

Image:1shs.png

Template:STRUCTURE 1shs

SMALL HEAT SHOCK PROTEIN FROM METHANOCOCCUS JANNASCHII

Template:ABSTRACT PUBMED 9707123

About this Structure

1SHS is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Crystal structure of a small heat-shock protein., Kim KK, Kim R, Kim SH, Nature. 1998 Aug 6;394(6693):595-9. PMID:9707123

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