1zax

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{{STRUCTURE_1zax| PDB=1zax | SCENE= }}
{{STRUCTURE_1zax| PDB=1zax | SCENE= }}
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'''Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form B'''
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===Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form B===
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==Overview==
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The L7/12 stalk of the large subunit of bacterial ribosomes encompasses protein L10 and multiple copies of L7/12. We present crystal structures of Thermotoga maritima L10 in complex with three L7/12 N-terminal-domain dimers, refine the structure of an archaeal L10E N-terminal domain on the 50S subunit, and identify these elements in cryo-electron-microscopic reconstructions of Escherichia coli ribosomes. The mobile C-terminal helix alpha8 of L10 carries three L7/12 dimers in T. maritima and two in E. coli, in concordance with the different length of helix alpha8 of L10 in these organisms. The stalk is organized into three elements (stalk base, L10 helix alpha8-L7/12 N-terminal-domain complex, and L7/12 C-terminal domains) linked by flexible connections. Highly mobile L7/12 C-terminal domains promote recruitment of translation factors to the ribosome and stimulate GTP hydrolysis by the ribosome bound factors through stabilization of their active GTPase conformation.
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{{ABSTRACT_PUBMED_15989950}}
==About this Structure==
==About this Structure==
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[[Category: Translation factor recruitment]]
[[Category: Translation factor recruitment]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:24:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:54:32 2008''

Revision as of 02:54, 28 July 2008

Image:1zax.png

Template:STRUCTURE 1zax

Ribosomal Protein L10-L12(NTD) Complex, Space Group P212121, Form B

Template:ABSTRACT PUBMED 15989950

About this Structure

1ZAX is a Protein complex structure of sequences from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Structural basis for the function of the ribosomal L7/12 stalk in factor binding and GTPase activation., Diaconu M, Kothe U, Schlunzen F, Fischer N, Harms JM, Tonevitsky AG, Stark H, Rodnina MV, Wahl MC, Cell. 2005 Jul 1;121(7):991-1004. PMID:15989950

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