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2o3s

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{{STRUCTURE_2o3s| PDB=2o3s | SCENE= }}
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'''Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38'''
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===Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38===
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==Overview==
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Human CD38 is a multifunctional ectoenzyme responsible for catalyzing the conversions from nicotinamide adenine dinucleotide (NAD) to cyclic ADP-ribose (cADPR) and from cADPR to ADP-ribose (ADPR). Both cADPR and ADPR are calcium messengers that can mobilize intracellular stores and activate influx as well. In this study, we determined three crystal structures of the human CD38 enzymatic domain complexed with cADPR at 1.5-A resolution, with its analog, cyclic GDP-ribose (cGDPR) (1.68 A) and with NGD (2.1 A) a substrate analog of NAD. The results indicate that the binding of cADPR or cGDPR to the active site induces structural rearrangements in the dipeptide Glu(146)-Asp(147) by as much as 2.7 A) providing the first direct evidence of a conformational change at the active site during catalysis. In addition, Glu(226) is shown to be critical not only in catalysis but also in positioning of cADPR at the catalytic site through strong hydrogen bonding interactions. Structural details obtained from these complexes provide a step-by-step description of the catalytic processes in the synthesis and hydrolysis of cADPR.
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{{ABSTRACT_PUBMED_17182614}}
==About this Structure==
==About this Structure==
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[[Category: Substrate binding]]
[[Category: Substrate binding]]
[[Category: The catalytic pocket]]
[[Category: The catalytic pocket]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:17:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:56:09 2008''

Revision as of 02:56, 28 July 2008

Image:2o3s.png

Template:STRUCTURE 2o3s

Structural Basis for Formation and Hydrolysis of Calcium Messenger Cyclic ADP-ribose by Human CD38

Template:ABSTRACT PUBMED 17182614

About this Structure

2O3S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38., Liu Q, Kriksunov IA, Graeff R, Lee HC, Hao Q, J Biol Chem. 2007 Feb 23;282(8):5853-61. Epub 2006 Dec 20. PMID:17182614

Page seeded by OCA on Mon Jul 28 05:56:09 2008

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