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2bay

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{{STRUCTURE_2bay| PDB=2bay | SCENE= }}
{{STRUCTURE_2bay| PDB=2bay | SCENE= }}
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'''Crystal structure of the Prp19 U-box dimer'''
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===Crystal structure of the Prp19 U-box dimer===
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==Overview==
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Prp19 is an essential splicing factor and a member of the U-box family of E3 ubiquitin ligases. Prp19 forms a tetramer via a central coiled-coil domain. Here, we show the U-box domain of Prp19 exists as a dimer within the context of the Prp19 tetramer. A high-resolution structure of the homodimeric state of the Prp19 U-box was determined by X-ray crystallography. Mutation of the U-box dimer interface abrogates U-box dimer formation and is lethal in vivo. The structure of the U-box dimer enables construction of a complete model of Prp19 providing insights into how the tetrameric protein functions as an E3 ligase. Finally, comparison of the Prp19 U-box homodimer with the heterodimeric complex of BRCA1/BARD1 RING-finger domains uncovers a common architecture for a family of oligomeric U-box and RING-finger E3 ubiquitin ligases, which has mechanistic implications for E3 ligase-mediated polyubiquitination and E4 polyubiquitin ligases.
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(as it appears on PubMed at http://www.pubmed.gov), where 16388587 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16388587}}
==About this Structure==
==About this Structure==
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[[Category: U-box]]
[[Category: U-box]]
[[Category: Ubiquitin ligase]]
[[Category: Ubiquitin ligase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:03:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:00:46 2008''

Revision as of 03:00, 28 July 2008

Image:2bay.png

Template:STRUCTURE 2bay

Crystal structure of the Prp19 U-box dimer

Template:ABSTRACT PUBMED 16388587

About this Structure

2BAY is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases., Vander Kooi CW, Ohi MD, Rosenberg JA, Oldham ML, Newcomer ME, Gould KL, Chazin WJ, Biochemistry. 2006 Jan 10;45(1):121-30. PMID:16388587

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