2hsp

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[[Image:2hsp.gif|left|200px]]
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{{STRUCTURE_2hsp| PDB=2hsp | SCENE= }}
{{STRUCTURE_2hsp| PDB=2hsp | SCENE= }}
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'''SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA'''
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===SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA===
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==Overview==
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SH3 (Src homology 3) domains are found in many signaling proteins and appear to function as binding modules for cytoplasmic target proteins. The solution structure of the SH3 domain of human phospholipase C-gamma (PLC-gamma) was determined by two-dimensional 1H NMR analysis. This SH3 domain is composed of eight antiparallel beta strands consisting of two successive "Greek key" motifs, which form a barrel-like structure. The conserved aliphatic and aromatic residues form a hydrophobic pocket on the molecular surface, and the conserved carboxylic residues are localized to the periphery. The hydrophobic pocket may serve as a binding site for target proteins. Analysis of the slowly exchanging amide protons by NMR measurements indicates that despite containing a high content of beta structure, the SH3 domain of PLC-gamma is flexible.
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(as it appears on PubMed at http://www.pubmed.gov), where 7681365 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7681365}}
==About this Structure==
==About this Structure==
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2HSP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hsp 1hsp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HSP OCA].
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2HSP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hsp 1hsp]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HSP OCA].
==Reference==
==Reference==
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[[Category: Odaka, M.]]
[[Category: Odaka, M.]]
[[Category: Phosphoric diester hydrolase]]
[[Category: Phosphoric diester hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:39:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:03:23 2008''

Revision as of 03:03, 28 July 2008

Image:2hsp.png

Template:STRUCTURE 2hsp

SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA

Template:ABSTRACT PUBMED 7681365

About this Structure

2HSP is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1hsp. Full experimental information is available from OCA.

Reference

Solution structure of the SH3 domain of phospholipase C-gamma., Kohda D, Hatanaka H, Odaka M, Mandiyan V, Ullrich A, Schlessinger J, Inagaki F, Cell. 1993 Mar 26;72(6):953-60. PMID:7681365

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