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2qna

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{{STRUCTURE_2qna| PDB=2qna | SCENE= }}
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'''Crystal structure of human Importin-beta (127-876) in complex with the IBB-domain of Snurportin1 (1-65)'''
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===Crystal structure of human Importin-beta (127-876) in complex with the IBB-domain of Snurportin1 (1-65)===
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==Overview==
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The nuclear import of assembled spliceosomal subunits, the uridine-rich small nuclear ribonucleoprotein particles (U snRNPs), is mediated by a nuclear import receptor adaptor couple of importin beta (Imp beta) and snurportin1 (SPN1). In contrast to any other characterized active nuclear import, the Imp beta/SPN1/U snRNP complex does not require RanGTP for the terminal release from the nuclear basket of the nuclear pore complex (NPC). The crystal structure of Imp beta (127-876) in complex with the Imp beta-binding (IBB) domain of SPN1 (1-65) at 2.8-A resolution reveals that Imp beta adopts an open conformation, which is unique for a functional Imp beta/cargo complex, and rather surprisingly, it resembles the conformation of the Imp beta/RanGTP complex. As binding of RanGTP to Imp beta usually triggers the release of import complexes from the NPC, we propose that by already mimicking a conformation similar to Imp beta/RanGTP the independent dissociation of Imp beta/SPN1 from the nuclear basket is energetically aided.
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{{ABSTRACT_PUBMED_18028944}}
==About this Structure==
==About this Structure==
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[[Category: Rna-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:05:41 2008''

Revision as of 03:05, 28 July 2008

Image:2qna.png

Template:STRUCTURE 2qna

Crystal structure of human Importin-beta (127-876) in complex with the IBB-domain of Snurportin1 (1-65)

Template:ABSTRACT PUBMED 18028944

About this Structure

2QNA is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus., Wohlwend D, Strasser A, Dickmanns A, Ficner R, J Mol Biol. 2007 Dec 7;374(4):1129-38. Epub 2007 Sep 29. PMID:18028944

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