1mzs

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{{STRUCTURE_1mzs| PDB=1mzs | SCENE= }}
{{STRUCTURE_1mzs| PDB=1mzs | SCENE= }}
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'''CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III WITH BOUND dichlorobenzyloxy-indole-carboxylic acid inhibitor'''
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===CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III WITH BOUND dichlorobenzyloxy-indole-carboxylic acid inhibitor===
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==Overview==
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The first cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor is reported. The inhibitor was obtained by rational modification of a high throughput screening lead with the aid of a S. pneumoniae FabH homology model. This homology model was used to design analogues that would have both high affinity for the enzyme and appropriate aqueous solubility to facilitate cocrystallization studies.
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(as it appears on PubMed at http://www.pubmed.gov), where 12502353 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12502353}}
==About this Structure==
==About this Structure==
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[[Category: Silverman, C.]]
[[Category: Silverman, C.]]
[[Category: Fabh]]
[[Category: Fabh]]
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Revision as of 03:07, 28 July 2008

Image:1mzs.png

Template:STRUCTURE 1mzs

CRYSTAL STRUCTURE OF BETA-KETOACYL-ACP SYNTHASE III WITH BOUND dichlorobenzyloxy-indole-carboxylic acid inhibitor

Template:ABSTRACT PUBMED 12502353

About this Structure

1MZS is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling., Daines RA, Pendrak I, Sham K, Van Aller GS, Konstantinidis AK, Lonsdale JT, Janson CA, Qiu X, Brandt M, Khandekar SS, Silverman C, Head MS, J Med Chem. 2003 Jan 2;46(1):5-8. PMID:12502353

Page seeded by OCA on Mon Jul 28 06:07:20 2008

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