1xdx

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{{STRUCTURE_1xdx| PDB=1xdx | SCENE= }}
{{STRUCTURE_1xdx| PDB=1xdx | SCENE= }}
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'''Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1'''
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===Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1===
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==Overview==
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Tctex1 is a light chain found in both cytoplasmic and flagellar dyneins and is involved in many fundamental cellular activities, including rhodopsin transport within photoreceptors, and may function in the non-Mendelian transmission of t haplotypes in mice. Here, we present the NMR solution structure for the Tctex1 dimer from Chlamydomonas axonemal inner dynein arm I1. Structural comparisons reveal a strong similarity with the LC8 dynein light chain dimer, including formation of a strand-switched beta sheet interface. Analysis of the Tctex1 structure enables the dynein intermediate chain binding site to be identified and suggests a mechanism by which cargo proteins might be attached to this microtubule motor complex. Comparison with the alternate dynein light chain rp3 reveals how the specificity of dynein-cargo interactions mediated by these dynein components is achieved. In addition, this structure provides insight into the consequences of the mutations found in the t haplotype forms of this protein.
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{{ABSTRACT_PUBMED_15698565}}
==About this Structure==
==About this Structure==
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1XDX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDX OCA].
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1XDX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XDX OCA].
==Reference==
==Reference==
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[[Category: Nmr solution structure]]
[[Category: Nmr solution structure]]
[[Category: Tctex1 dimer]]
[[Category: Tctex1 dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:54:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:11:12 2008''

Revision as of 03:11, 28 July 2008

Image:1xdx.png

Template:STRUCTURE 1xdx

Solution Structure of the Tctex1 Light Chain From Chlamydomonas Inner Dynein Arm I1

Template:ABSTRACT PUBMED 15698565

About this Structure

1XDX is a Single protein structure of sequence from Chlamydomonas reinhardtii. Full experimental information is available from OCA.

Reference

Solution structure of the Tctex1 dimer reveals a mechanism for dynein-cargo interactions., Wu H, Maciejewski MW, Takebe S, King SM, Structure. 2005 Feb;13(2):213-23. PMID:15698565

Page seeded by OCA on Mon Jul 28 06:11:12 2008

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