1u25

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{{STRUCTURE_1u25| PDB=1u25 | SCENE= }}
{{STRUCTURE_1u25| PDB=1u25 | SCENE= }}
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'''Crystal structure of Selenomonas ruminantium phytase complexed with persulfated phytate in the C2221 crystal form'''
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===Crystal structure of Selenomonas ruminantium phytase complexed with persulfated phytate in the C2221 crystal form===
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==Overview==
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Various inositide phosphatases participate in the regulation of inositol polyphosphate signaling molecules. Plant phytases are phosphatases that hydrolyze phytate to less-phosphorylated myo-inositol derivatives and phosphate. The phytase from Selenomonas ruminantium shares no sequence homology with other microbial phytases. Its crystal structure revealed a phytase fold of the dual-specificity phosphatase type. The active site is located near a conserved cysteine-containing (Cys241) P loop. We also solved two other crystal forms in which an inhibitor, myo-inositol hexasulfate, is cocrystallized with the enzyme. In the "standby" and the "inhibited" crystal forms, the inhibitor is bound, respectively, in a pocket slightly away from Cys241 and at the substrate binding site where the phosphate group to be hydrolyzed is held close to the -SH group of Cys241. Our structural and mutagenesis studies allow us to visualize the way in which the P loop-containing phytase attracts and hydrolyzes the substrate (phytate) sequentially.
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(as it appears on PubMed at http://www.pubmed.gov), where 15530366 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15530366}}
==About this Structure==
==About this Structure==
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[[Category: Phytase]]
[[Category: Phytase]]
[[Category: Ptp]]
[[Category: Ptp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:39:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:16:47 2008''

Revision as of 03:16, 28 July 2008

Image:1u25.png

Template:STRUCTURE 1u25

Crystal structure of Selenomonas ruminantium phytase complexed with persulfated phytate in the C2221 crystal form

Template:ABSTRACT PUBMED 15530366

About this Structure

1U25 is a Single protein structure of sequence from Selenomonas ruminantium. Full crystallographic information is available from OCA.

Reference

Structures of Selenomonas ruminantium phytase in complex with persulfated phytate: DSP phytase fold and mechanism for sequential substrate hydrolysis., Chu HM, Guo RT, Lin TW, Chou CC, Shr HL, Lai HL, Tang TY, Cheng KJ, Selinger BL, Wang AH, Structure. 2004 Nov;12(11):2015-24. PMID:15530366

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