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1x0s

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{{STRUCTURE_1x0s| PDB=1x0s | SCENE= }}
{{STRUCTURE_1x0s| PDB=1x0s | SCENE= }}
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'''Crystal structure of the 13-cis isomer of bacteriorhodopsin'''
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===Crystal structure of the 13-cis isomer of bacteriorhodopsin===
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==Overview==
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The atomic structure of the trans isomer of bacteriorhodopsin was determined previously by using a 3D crystal belonging to the space group P622. Here, a structure is reported for another isomer with the 13-cis, 15-syn retinal in a dark-adapted crystal. Structural comparison of the two isomers indicates that retinal isomerization around the C13[double bond]C14 and the C15[double bond]N bonds is accompanied by noticeable displacements of a few residues in the vicinity of the retinal Schiff base and small re-arrangement of the hydrogen-bonding network in the proton release channel. On the other hand, aromatic residues surrounding the retinal polyene chain were found to scarcely move during the dark/light adaptation. This result suggests that variation in the structural rigidity within the retinal-binding pocket is one of the important factors ensuring the stereospecific isomerization of retinal.
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(as it appears on PubMed at http://www.pubmed.gov), where 16084526 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16084526}}
==About this Structure==
==About this Structure==
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[[Category: Proton pump]]
[[Category: Proton pump]]
[[Category: Retinal]]
[[Category: Retinal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:23:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:16:52 2008''

Revision as of 03:16, 28 July 2008

Template:STRUCTURE 1x0s

Crystal structure of the 13-cis isomer of bacteriorhodopsin

Template:ABSTRACT PUBMED 16084526

About this Structure

1X0S is a Single protein structure of sequence from Halobacterium salinarum. Full crystallographic information is available from OCA.

Reference

Crystal structure of the 13-cis isomer of bacteriorhodopsin in the dark-adapted state., Nishikawa T, Murakami M, Kouyama T, J Mol Biol. 2005 Sep 16;352(2):319-28. PMID:16084526

Page seeded by OCA on Mon Jul 28 06:16:52 2008

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