3bdw

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{{STRUCTURE_3bdw| PDB=3bdw | SCENE= }}
{{STRUCTURE_3bdw| PDB=3bdw | SCENE= }}
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'''Human CD94/NKG2A'''
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===Human CD94/NKG2A===
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==Overview==
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The CD94-NKG2 receptor family that regulates NK and T cells is unique among the lectin-like receptors encoded within the natural killer cell complex. The function of the CD94-NKG2 receptors is dictated by the pairing of the invariant CD94 polypeptide with specific NKG2 isoforms to form a family of functionally distinct heterodimeric receptors. However, the structural basis for this selective pairing and how they interact with their ligand, HLA-E, is unknown. We describe the 2.5 A resolution crystal structure of CD94-NKG2A in which the mode of dimerization contrasts with that of other homodimeric NK receptors. Despite structural homology between the CD94 and NKG2A subunits, the dimer interface is asymmetric, thereby providing a structural basis for the preferred heterodimeric assembly. Structure-based sequence comparisons of other CD94-NKG2 family members, combined with extensive mutagenesis studies on HLA-E and CD94-NKG2A, allows a model of the interaction between CD94-NKG2A and HLA-E to be established, in which the invariant CD94 chain plays a more dominant role in interacting with HLA-E in comparison to the variable NKG2 chain.
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(as it appears on PubMed at http://www.pubmed.gov), where 18083576 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18083576}}
==About this Structure==
==About this Structure==
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[[Category: Signal-anchor]]
[[Category: Signal-anchor]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:40:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:16:58 2008''

Revision as of 03:17, 28 July 2008

Image:3bdw.png

Template:STRUCTURE 3bdw

Human CD94/NKG2A

Template:ABSTRACT PUBMED 18083576

About this Structure

3BDW is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition., Sullivan LC, Clements CS, Beddoe T, Johnson D, Hoare HL, Lin J, Huyton T, Hopkins EJ, Reid HH, Wilce MC, Kabat J, Borrego F, Coligan JE, Rossjohn J, Brooks AG, Immunity. 2007 Dec;27(6):900-11. PMID:18083576

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