1lq1
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(New page: 200px<br /><applet load="1lq1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lq1, resolution 2.3Å" /> '''DNA Complexed Structu...)
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Revision as of 18:39, 20 November 2007
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DNA Complexed Structure of the Key Transcription Factor Initiating Development in Sporulation Bacteria
Overview
Sporulation in Bacillus species, the ultimate bacterial adaptive response, requires the precisely coordinated expression of a complex genetic, pathway, and is initiated through the accumulation of the phosphorylated, form of Spo0A, a pleiotropic response regulator transcription factor., Spo0A controls the transcription of several hundred genes in all, spore-forming Bacilli including genes for sporulation and toxin regulation, in pathogens such as Bacillus anthracis. The crystal structure of the, effector domain of Spo0A from Bacillus subtilis in complex with its DNA, target was determined. In the crystal lattice, two molecules form a tandem, dimer upon binding to adjacent sites on DNA. The protein:protein and, protein:DNA interfaces revealed in the crystal provide a basis for, interpreting the transcription activation process and for the design of, drugs to counter infections by these bacteria.
About this Structure
1LQ1 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
DNA complexed structure of the key transcription factor initiating development in sporulating bacteria., Zhao H, Msadek T, Zapf J, Madhusudan, Hoch JA, Varughese KI, Structure. 2002 Aug;10(8):1041-50. PMID:12176382
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