1msb

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{{STRUCTURE_1msb| PDB=1msb | SCENE= }}
{{STRUCTURE_1msb| PDB=1msb | SCENE= }}
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'''STRUCTURE OF THE CALCIUM-DEPENDENT LECTIN DOMAIN FROM A RAT MANNOSE-BINDING PROTEIN DETERMINED BY MAD PHASING'''
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===STRUCTURE OF THE CALCIUM-DEPENDENT LECTIN DOMAIN FROM A RAT MANNOSE-BINDING PROTEIN DETERMINED BY MAD PHASING===
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==Overview==
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Calcium-dependent (C-type) animal lectins participate in many cell surface recognition events mediated by protein-carbohydrate interactions. The C-type lectin family includes cell adhesion molecules, endocytic receptors, and extracellular matrix proteins. Mammalian mannose-binding proteins are C-type lectins that function in antibody-independent host defense against pathogens. The crystal structure of the carbohydrate-recognition domain of a rat mannose-binding protein, determined as the holmium-substituted complex by multiwavelength anomalous dispersion (MAD) phasing, reveals an unusual fold consisting of two distinct regions, one of which contains extensive nonregular secondary structure stabilized by two holmium ions. The structure explains the conservation of 32 residues in all C-type carbohydrate-recognition domains, suggesting that the fold seen here is common to these domains. The strong anomalous scattering observed at the Ho LIII edge demonstrates that traditional heavy atom complexes will be generally amenable to the MAD phasing method.
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{{ABSTRACT_PUBMED_1721241}}
==About this Structure==
==About this Structure==
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[[Category: Weis, W I.]]
[[Category: Weis, W I.]]
[[Category: Hepatic lectin]]
[[Category: Hepatic lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:39:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:20:08 2008''

Revision as of 03:20, 28 July 2008

Image:1msb.png

Template:STRUCTURE 1msb

STRUCTURE OF THE CALCIUM-DEPENDENT LECTIN DOMAIN FROM A RAT MANNOSE-BINDING PROTEIN DETERMINED BY MAD PHASING

Template:ABSTRACT PUBMED 1721241

About this Structure

1MSB is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the calcium-dependent lectin domain from a rat mannose-binding protein determined by MAD phasing., Weis WI, Kahn R, Fourme R, Drickamer K, Hendrickson WA, Science. 1991 Dec 13;254(5038):1608-15. PMID:1721241

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