2hbj

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[[Image:2hbj.gif|left|200px]]
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{{STRUCTURE_2hbj| PDB=2hbj | SCENE= }}
{{STRUCTURE_2hbj| PDB=2hbj | SCENE= }}
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'''Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active site and the HRDC domain'''
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===Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active site and the HRDC domain===
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==Overview==
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The multisubunit eukaryotic exosome is an essential RNA processing and degradation machine. In its nuclear form, the exosome associates with the auxiliary factor Rrp6p, which participates in both RNA processing and degradation reactions. The crystal structure of Saccharomyces cerevisiae Rrp6p displays a conserved RNase D core with a flanking HRDC (helicase and RNase D C-terminal) domain in an unusual conformation shown to be important for the processing function of the enzyme. Complexes with AMP and UMP, the products of the RNA degradation process, reveal how the protein specifically recognizes ribonucleotides and their bases. Finally, in vivo mutational studies show the importance of the domain contacts for the processing function of Rrp6p and highlight fundamental differences between the protein and its prokaryotic RNase D counterparts.
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(as it appears on PubMed at http://www.pubmed.gov), where 16882719 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16882719}}
==About this Structure==
==About this Structure==
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[[Category: Rna processing]]
[[Category: Rna processing]]
[[Category: Rna surveillance]]
[[Category: Rna surveillance]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:05:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:22:48 2008''

Revision as of 03:22, 28 July 2008

Image:2hbj.png

Template:STRUCTURE 2hbj

Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active site and the HRDC domain

Template:ABSTRACT PUBMED 16882719

About this Structure

2HBJ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of the nuclear exosome component Rrp6p reveals an interplay between the active site and the HRDC domain., Midtgaard SF, Assenholt J, Jonstrup AT, Van LB, Jensen TH, Brodersen DE, Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11898-903. Epub 2006 Aug 1. PMID:16882719

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