1ujl

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[[Image:1ujl.gif|left|200px]]
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{{Seed}}
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[[Image:1ujl.png|left|200px]]
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{{STRUCTURE_1ujl| PDB=1ujl | SCENE= }}
{{STRUCTURE_1ujl| PDB=1ujl | SCENE= }}
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'''Solution Structure of the HERG K+ channel S5-P extracellular linker'''
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===Solution Structure of the HERG K+ channel S5-P extracellular linker===
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==Overview==
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The HERG K+ channel has very unusual kinetic behaviour that includes slow activation but rapid inactivation. These features are critical for normal cardiac repolarisation as well as in preventing lethal ventricular arrhythmias. Extensive mutagenesis of the HERG K+ channel has allowed identification of which regions of the channel are important for the unusual kinetic behaviour of the channel. Furthermore, structural studies on scorpion toxins that potently inhibit HERG are beginning to provide clues as to the structural differences between HERG and other voltage-gated K+ channels.
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The line below this paragraph, {{ABSTRACT_PUBMED_13680209}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 13680209 is the PubMed ID number.
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{{ABSTRACT_PUBMED_13680209}}
==About this Structure==
==About this Structure==
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1UJL is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJL OCA].
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1UJL is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UJL OCA].
==Reference==
==Reference==
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[[Category: Amphiphatic helix]]
[[Category: Amphiphatic helix]]
[[Category: Two helice]]
[[Category: Two helice]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:18:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:22:59 2008''

Revision as of 03:23, 28 July 2008

Image:1ujl.png

Template:STRUCTURE 1ujl

Solution Structure of the HERG K+ channel S5-P extracellular linker

Template:ABSTRACT PUBMED 13680209

About this Structure

1UJL is a Single protein structure. Full experimental information is available from OCA.

Reference

The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics., Vandenberg JI, Torres AM, Campbell TJ, Kuchel PW, Eur Biophys J. 2004 Apr;33(2):89-97. Epub 2003 Sep 10. PMID:13680209

Page seeded by OCA on Mon Jul 28 06:22:59 2008

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