2fo1

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[[Image:2fo1.gif|left|200px]]
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{{STRUCTURE_2fo1| PDB=2fo1 | SCENE= }}
{{STRUCTURE_2fo1| PDB=2fo1 | SCENE= }}
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'''Crystal Structure of the CSL-Notch-Mastermind ternary complex bound to DNA'''
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===Crystal Structure of the CSL-Notch-Mastermind ternary complex bound to DNA===
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==Overview==
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Notch signaling mediates communication between cells and is essential for proper embryonic patterning and development. CSL is a DNA binding transcription factor that regulates transcription of Notch target genes by interacting with coregulators. Transcriptional activation requires the displacement of corepressors from CSL by the intracellular portion of the receptor Notch (NotchIC) and the recruitment of the coactivator protein Mastermind to the complex. Here we report the 3.1 A structure of the ternary complex formed by CSL, NotchIC, and Mastermind bound to DNA. As expected, the RAM domain of Notch interacts with the beta trefoil domain of CSL; however, the C-terminal domain of CSL has an unanticipated central role in the interface formed with the Notch ankyrin repeats and Mastermind. Ternary complex formation induces a substantial conformational change within CSL, suggesting a molecular mechanism for the conversion of CSL from a repressor to an activator.
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(as it appears on PubMed at http://www.pubmed.gov), where 16530045 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16530045}}
==About this Structure==
==About this Structure==
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[[Category: Double helix]]
[[Category: Double helix]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:07:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:28:43 2008''

Revision as of 03:28, 28 July 2008

Image:2fo1.png

Template:STRUCTURE 2fo1

Crystal Structure of the CSL-Notch-Mastermind ternary complex bound to DNA

Template:ABSTRACT PUBMED 16530045

About this Structure

2FO1 is a Protein complex structure of sequences from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA., Wilson JJ, Kovall RA, Cell. 2006 Mar 10;124(5):985-96. PMID:16530045

Page seeded by OCA on Mon Jul 28 06:28:43 2008

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