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3bwu

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{{STRUCTURE_3bwu| PDB=3bwu | SCENE= }}
{{STRUCTURE_3bwu| PDB=3bwu | SCENE= }}
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'''Crystal structure of the ternary complex of FimD (N-Terminal Domain, FimDN) with FimC and the N-terminally truncated pilus subunit FimF (FimFt)'''
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===Crystal structure of the ternary complex of FimD (N-Terminal Domain, FimDN) with FimC and the N-terminally truncated pilus subunit FimF (FimFt)===
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==Overview==
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Type 1 pili, anchored to the outer membrane protein FimD, enable uropathogenic Escherichia coli to attach to host cells. During pilus biogenesis, the N-terminal periplasmic domain of FimD (FimD(N)) binds complexes between the chaperone FimC and pilus subunits via its partly disordered N-terminal segment, as recently shown for the FimC-FimH(P)-FimD(N) ternary complex. We report the structure of a new ternary complex (FimC-FimF(t)-FimD(N)) with the subunit FimF(t) instead of FimH(p). FimD(N) recognizes FimC-FimF(t) and FimC-FimH(P) very similarly, predominantly through hydrophobic interactions. The conserved binding mode at a "hot spot" on the chaperone surface could guide the design of pilus assembly inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 18242189 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18242189}}
==About this Structure==
==About this Structure==
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[[Category: Ternary complex with chaperone and pilus subunit]]
[[Category: Ternary complex with chaperone and pilus subunit]]
[[Category: Usher]]
[[Category: Usher]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 21:10:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:29:10 2008''

Revision as of 03:29, 28 July 2008

Image:3bwu.png

Template:STRUCTURE 3bwu

Crystal structure of the ternary complex of FimD (N-Terminal Domain, FimDN) with FimC and the N-terminally truncated pilus subunit FimF (FimFt)

Template:ABSTRACT PUBMED 18242189

About this Structure

3BWU is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the ternary FimC-FimF(t)-FimD(N) complex indicates conserved pilus chaperone-subunit complex recognition by the usher FimD., Eidam O, Dworkowski FS, Glockshuber R, Grutter MG, Capitani G, FEBS Lett. 2008 Mar 5;582(5):651-5. Epub 2008 Jan 31. PMID:18242189

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