1uw1

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[[Image:1uw1.jpg|left|200px]]
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{{Seed}}
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[[Image:1uw1.png|left|200px]]
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{{STRUCTURE_1uw1| PDB=1uw1 | SCENE= }}
{{STRUCTURE_1uw1| PDB=1uw1 | SCENE= }}
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'''A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION'''
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===A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION===
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==Overview==
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A great challenge to biologists is to create proteins with novel folds and tailored functions. As an alternative to de novo protein design, we investigated the structure of a randomly generated protein targeted to bind ATP. The crystal structure reveals a novel alpha/beta fold bound to its ligand, representing both the first protein structure derived from in vitro evolution and the first nucleotide-binding protein stabilized by a zinc ion.
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The line below this paragraph, {{ABSTRACT_PUBMED_15024384}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15024384 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15024384}}
==About this Structure==
==About this Structure==
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[[Category: In vitro evolution]]
[[Category: In vitro evolution]]
[[Category: Nucleotide binding protein]]
[[Category: Nucleotide binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:45:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:30:35 2008''

Revision as of 03:30, 28 July 2008

Image:1uw1.png

Template:STRUCTURE 1uw1

A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION

Template:ABSTRACT PUBMED 15024384

About this Structure

1UW1 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:15024384

Page seeded by OCA on Mon Jul 28 06:30:35 2008

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