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1wdy

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[[Image:1wdy.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1wdy| PDB=1wdy | SCENE= }}
{{STRUCTURE_1wdy| PDB=1wdy | SCENE= }}
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'''Crystal structure of ribonuclease'''
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===Crystal structure of ribonuclease===
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==Overview==
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An interferon-induced endoribonuclease, ribonuclease L (RNase L), is implicated in both the molecular mechanism of action of interferon and the fundamental control of RNA stability in mammalian cells. RNase L is catalytically active only after binding to an unusual activator molecule containing a 5'-phosphorylated 2',5'-linked oligoadenylate (2-5A), in the N-terminal half. Here, we report the crystal structure of the N-terminal ankyrin repeat domain (ANK) of human RNase L complexed with the activator 2-5A. This is the first structural view of an ankyrin repeat structure directly interacting with a nucleic acid, rather than with a protein. The ANK domain folds into eight ankyrin repeat elements and forms an extended curved structure with a concave surface. The 2-5A molecule is accommodated at a concave site and directly interacts with ankyrin repeats 2-4. Interestingly, two structurally equivalent 2-5A binding motifs are found at repeats 2 and 4. The structural basis for 2-5A recognition by ANK is essential for designing stable 2-5As with a high likelihood of activating RNase L.
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The line below this paragraph, {{ABSTRACT_PUBMED_15385955}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15385955 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15385955}}
==About this Structure==
==About this Structure==
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[[Category: Nuclease]]
[[Category: Nuclease]]
[[Category: Rna-binding]]
[[Category: Rna-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:31:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:31:53 2008''

Revision as of 03:31, 28 July 2008

Image:1wdy.png

Template:STRUCTURE 1wdy

Crystal structure of ribonuclease

Template:ABSTRACT PUBMED 15385955

About this Structure

1WDY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L., Tanaka N, Nakanishi M, Kusakabe Y, Goto Y, Kitade Y, Nakamura KT, EMBO J. 2004 Oct 13;23(20):3929-38. Epub 2004 Sep 23. PMID:15385955

Page seeded by OCA on Mon Jul 28 06:31:53 2008

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