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2agv

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[[Image:2agv.gif|left|200px]]
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[[Image:2agv.png|left|200px]]
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{{STRUCTURE_2agv| PDB=2agv | SCENE= }}
{{STRUCTURE_2agv| PDB=2agv | SCENE= }}
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'''Crystal structure of the SR CA2+-ATPASE with BHQ and TG'''
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===Crystal structure of the SR CA2+-ATPASE with BHQ and TG===
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==Overview==
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Ca(2+)-ATPase of sarcoplasmic reticulum is an ATP-powered Ca(2+) pump but also a H(+) pump in the opposite direction with no demonstrated functional role. Here, we report a 2.4-A-resolution crystal structure of the Ca(2+)-ATPase in the absence of Ca(2+) stabilized by two inhibitors, dibutyldihydroxybenzene, which bridges two transmembrane helices, and thapsigargin, also bound in the membrane region. Now visualized are water and several phospholipid molecules, one of which occupies a cleft between two transmembrane helices. Atomic models of the Ca(2+) binding sites with explicit hydrogens derived by continuum electrostatic calculations show how water and protons fill the space and compensate charge imbalance created by Ca(2+)-release. They suggest that H(+) countertransport is a consequence of a requirement for maintaining structural integrity of the empty Ca(2+)-binding sites. For this reason, cation countertransport is probably mandatory for all P-type ATPases and possibly accompanies transport of water as well.
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The line below this paragraph, {{ABSTRACT_PUBMED_16150713}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16150713 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16150713}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structural role of countertransport revealed in Ca(2+) pump crystal structure in the absence of Ca(2+)., Obara K, Miyashita N, Xu C, Toyoshima I, Sugita Y, Inesi G, Toyoshima C, Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14489-96. Epub 2005 Sep 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16150713 16150713]
Structural role of countertransport revealed in Ca(2+) pump crystal structure in the absence of Ca(2+)., Obara K, Miyashita N, Xu C, Toyoshima I, Sugita Y, Inesi G, Toyoshima C, Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14489-96. Epub 2005 Sep 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16150713 16150713]
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Structural biology. Pumping ions., MacLennan DH, Green NM, Nature. 2000 Jun 8;405(6787):633-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10864310 10864310]
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Calcium callisthenics., Green NM, MacLennan DH, Nature. 2002 Aug 8;418(6898):598-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12167844 12167844]
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Crystal structure of the calcium pump with a bound ATP analogue., Toyoshima C, Mizutani T, Nature. 2004 Jul 29;430(6999):529-35. Epub 2004 Jun 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15229613 15229613]
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Structural biology: ion pump in the movies., Lancaster CR, Nature. 2004 Nov 18;432(7015):286-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15549083 15549083]
[[Category: Calcium-transporting ATPase]]
[[Category: Calcium-transporting ATPase]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: P-type atpase]]
[[Category: P-type atpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:01:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:35:33 2008''

Revision as of 03:35, 28 July 2008

Image:2agv.png

Template:STRUCTURE 2agv

Crystal structure of the SR CA2+-ATPASE with BHQ and TG

Template:ABSTRACT PUBMED 16150713

About this Structure

2AGV is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Structural role of countertransport revealed in Ca(2+) pump crystal structure in the absence of Ca(2+)., Obara K, Miyashita N, Xu C, Toyoshima I, Sugita Y, Inesi G, Toyoshima C, Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14489-96. Epub 2005 Sep 6. PMID:16150713

Structural biology. Pumping ions., MacLennan DH, Green NM, Nature. 2000 Jun 8;405(6787):633-4. PMID:10864310

Calcium callisthenics., Green NM, MacLennan DH, Nature. 2002 Aug 8;418(6898):598-9. PMID:12167844

Crystal structure of the calcium pump with a bound ATP analogue., Toyoshima C, Mizutani T, Nature. 2004 Jul 29;430(6999):529-35. Epub 2004 Jun 30. PMID:15229613

Structural biology: ion pump in the movies., Lancaster CR, Nature. 2004 Nov 18;432(7015):286-7. PMID:15549083

Page seeded by OCA on Mon Jul 28 06:35:33 2008

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