1sdm

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{{STRUCTURE_1sdm| PDB=1sdm | SCENE= }}
{{STRUCTURE_1sdm| PDB=1sdm | SCENE= }}
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'''Crystal structure of kinesin-like calmodulin binding protein'''
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===Crystal structure of kinesin-like calmodulin binding protein===
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==Overview==
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Kinesins orchestrate cell division by controlling placement of chromosomes. Kinesins must be precisely regulated or else cell division fails. Calcium, a universal second messenger in eukaryotes, and calmodulin regulate some kinesins by causing the motor to dissociate from its biological track, the microtubule. Our focus was the mechanism of calcium regulation of kinesin at atomic resolution. Here we report the crystal structure of kinesin-like calmodulin-binding protein (KCBP) from potato, which was resolved to 2.3 A. The structure reveals three subdomains of the regulatory machinery located at the C terminus extension of the kinesin motor. Calmodulin that is activated by Ca2+ ions binds to an alpha-helix positioned on the microtubule-binding face of kinesin. A negatively charged segment following this helix competes with microtubules. A mimic of the conventional kinesin neck, connecting the calmodulin-binding helix to the KCBP motor core, links the regulatory machine to the kinesin catalytic cycle. Together with biochemical data, the crystal structure suggests that Ca(2+)-calmodulin inhibits the binding of KCBP to microtubules by blocking the microtubule-binding sites on KCBP.
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The line below this paragraph, {{ABSTRACT_PUBMED_14988396}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14988396 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14988396}}
==About this Structure==
==About this Structure==
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[[Category: Kinesin]]
[[Category: Kinesin]]
[[Category: Minus-end directed]]
[[Category: Minus-end directed]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:34:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:37:41 2008''

Revision as of 03:37, 28 July 2008

Image:1sdm.png

Template:STRUCTURE 1sdm

Crystal structure of kinesin-like calmodulin binding protein

Template:ABSTRACT PUBMED 14988396

About this Structure

1SDM is a Single protein structure of sequence from Solanum tuberosum. Full crystallographic information is available from OCA.

Reference

Crystal structure of kinesin regulated by Ca(2+)-calmodulin., Vinogradova MV, Reddy VS, Reddy AS, Sablin EP, Fletterick RJ, J Biol Chem. 2004 May 28;279(22):23504-9. Epub 2004 Feb 26. PMID:14988396

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