1s3q

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{{STRUCTURE_1s3q| PDB=1s3q | SCENE= }}
{{STRUCTURE_1s3q| PDB=1s3q | SCENE= }}
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'''Crystal structures of a novel open pore ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus'''
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===Crystal structures of a novel open pore ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus===
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==Overview==
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Ferritins are known as important iron storage/detoxification proteins and are widely found in living organisms. This report details the 2.1 A resolution native and 2.7 A resolution iron bound structures of the ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus, and represents the first structure of a ferritin from an archaeon, or a hyperthermophilic organism. The A. fulgidus ferritin (AfFtn) monomer has a high degree of structural similarity with archetypal ferritins from E. coli and humans, but the AfFtn quaternary structure is novel; 24 subunits assemble into a shell having tetrahedral (2-3) rather than the canonical octahedral (4-3-2) symmetry of archetypal ferritins. The difference in assembly opens four large (approximately 45 A) pores in the AfFtn shell. Two nonconservative amino acid substitutions may be critical for stabilizing the tetrahedral form.
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(as it appears on PubMed at http://www.pubmed.gov), where 15837202 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15837202}}
==About this Structure==
==About this Structure==
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[[Category: Four helix bundle]]
[[Category: Four helix bundle]]
[[Category: Iron storage]]
[[Category: Iron storage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:15:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:38:32 2008''

Revision as of 03:38, 28 July 2008

Image:1s3q.png

Template:STRUCTURE 1s3q

Crystal structures of a novel open pore ferritin from the hyperthermophilic Archaeon Archaeoglobus fulgidus

Template:ABSTRACT PUBMED 15837202

About this Structure

1S3Q is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

Crystal structures of a tetrahedral open pore ferritin from the hyperthermophilic archaeon Archaeoglobus fulgidus., Johnson E, Cascio D, Sawaya MR, Gingery M, Schroder I, Structure. 2005 Apr;13(4):637-48. PMID:15837202

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