1muk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1muk.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1muk.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1muk| PDB=1muk | SCENE= }}
{{STRUCTURE_1muk| PDB=1muk | SCENE= }}
-
'''reovirus lambda3 native structure'''
+
===reovirus lambda3 native structure===
-
==Overview==
+
<!--
-
The reovirus polymerase and those of other dsRNA viruses function within the confines of a protein capsid to transcribe the tightly packed dsRNA genome segments. The crystal structure of the reovirus polymerase, lambda3, determined at 2.5 A resolution, shows a fingers-palm-thumb core, similar to those of other viral polymerases, surrounded by major N- and C-terminal elaborations, which create a cage-like structure, with four channels leading to the catalytic site. This "caged" polymerase has allowed us to visualize the results of several rounds of RNA polymerization directly in the crystals. A 5' cap binding site on the surface of lambda3 suggests a template retention mechanism by which attachment of the 5' end of the plus-sense strand facilitates insertion of the 3' end of the minus-sense strand into the template channel.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12464184}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12464184 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12464184}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Single subunit polymerase fold]]
[[Category: Single subunit polymerase fold]]
[[Category: Thumb]]
[[Category: Thumb]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:44:21 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:39:59 2008''

Revision as of 03:40, 28 July 2008

Image:1muk.png

Template:STRUCTURE 1muk

reovirus lambda3 native structure

Template:ABSTRACT PUBMED 12464184

About this Structure

1MUK is a Single protein structure of sequence from Reovirus sp.. Full crystallographic information is available from OCA.

Reference

RNA synthesis in a cage--structural studies of reovirus polymerase lambda3., Tao Y, Farsetta DL, Nibert ML, Harrison SC, Cell. 2002 Nov 27;111(5):733-45. PMID:12464184

Page seeded by OCA on Mon Jul 28 06:39:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1muk"
Personal tools