3b74

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{{STRUCTURE_3b74| PDB=3b74 | SCENE= }}
{{STRUCTURE_3b74| PDB=3b74 | SCENE= }}
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'''Crystal Structure of Yeast Sec14 Homolog Sfh1 in Complex with Phosphatidylethanolamine'''
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===Crystal Structure of Yeast Sec14 Homolog Sfh1 in Complex with Phosphatidylethanolamine===
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==Overview==
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Sec14, the major yeast phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer protein, regulates essential interfaces between lipid metabolism and membrane trafficking from the trans-Golgi network (TGN). How Sec14 does so remains unclear. We report that Sec14 binds PtdIns and PtdCho at distinct (but overlapping) sites, and both PtdIns- and PtdCho-binding activities are essential Sec14 activities. We further show both activities must reside within the same molecule to reconstitute a functional Sec14 and for effective Sec14-mediated regulation of phosphoinositide homeostasis in vivo. This regulation is uncoupled from PtdIns-transfer activity and argues for an interfacial presentation mode for Sec14-mediated potentiation of PtdIns kinases. Such a regulatory role for Sec14 is a primary counter to action of the Kes1 sterol-binding protein that antagonizes PtdIns 4-OH kinase activity in vivo. Collectively, these findings outline functional mechanisms for the Sec14 superfamily and reveal additional layers of complexity for regulating phosphoinositide homeostasis in eukaryotes.
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(as it appears on PubMed at http://www.pubmed.gov), where 18243114 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18243114}}
==About this Structure==
==About this Structure==
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[[Category: Sec14]]
[[Category: Sec14]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:27:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:43:15 2008''

Revision as of 03:43, 28 July 2008

Image:3b74.png

Template:STRUCTURE 3b74

Crystal Structure of Yeast Sec14 Homolog Sfh1 in Complex with Phosphatidylethanolamine

Template:ABSTRACT PUBMED 18243114

About this Structure

3B74 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily., Schaaf G, Ortlund EA, Tyeryar KR, Mousley CJ, Ile KE, Garrett TA, Ren J, Woolls MJ, Raetz CR, Redinbo MR, Bankaitis VA, Mol Cell. 2008 Feb 1;29(2):191-206. PMID:18243114

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