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1utr

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[[Image:1utr.jpg|left|200px]]
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{{STRUCTURE_1utr| PDB=1utr | SCENE= }}
{{STRUCTURE_1utr| PDB=1utr | SCENE= }}
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'''UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)'''
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===UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)===
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==Overview==
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Metabolites of polychlorinated biphenyls (PCBs) bind with high affinity to uteroglobin, a small homodimeric protein that also binds progesterone. We present the solution structure of the reduced form of rat uteroglobin in complex with a PCB methylsulphone, (MeSO2)2-TCB. The structure reveals the molecular basis for the accumulation of (MeSO2)2-TCB by uteroglobin. The structure also shows how ligand binding and release might be controlled by reduction/oxidation of two intermolecular disulphide bonds. Breakage of these bonds induces a local unfolding of the N- and C-termini and a separation of helices creating a channel into the binding site. These effects make the ligand binding cavity readily accessible to entry of the ligand.
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The line below this paragraph, {{ABSTRACT_PUBMED_7583672}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7583672 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7583672}}
==About this Structure==
==About this Structure==
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1UTR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTR OCA].
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1UTR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UTR OCA].
==Reference==
==Reference==
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[[Category: Progesterone binding]]
[[Category: Progesterone binding]]
[[Category: Uteroglobin]]
[[Category: Uteroglobin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:40:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:43:02 2008''

Revision as of 03:43, 28 July 2008

Image:1utr.png

Template:STRUCTURE 1utr

UTEROGLOBIN-PCB COMPLEX (REDUCED FORM)

Template:ABSTRACT PUBMED 7583672

About this Structure

1UTR is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Solution structure of a mammalian PCB-binding protein in complex with a PCB., Hard T, Barnes HJ, Larsson C, Gustafsson JA, Lund J, Nat Struct Biol. 1995 Nov;2(11):983-9. PMID:7583672

Page seeded by OCA on Mon Jul 28 06:43:02 2008

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