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1q59

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[[Image:1q59.gif|left|200px]]
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{{STRUCTURE_1q59| PDB=1q59 | SCENE= }}
{{STRUCTURE_1q59| PDB=1q59 | SCENE= }}
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'''Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2'''
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===Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2===
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==Overview==
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The three-dimensional structure of BHRF1, the Bcl-2 homolog from Epstein-Barr virus (EBV), has been determined by NMR spectroscopy. Although the overall structure is similar to other Bcl-2 family members, there are important structural differences. Unlike some of the other Bcl-2 family members, BHRF1 does not contain the prominent hydrophobic groove that mediates binding to pro-apoptotic family members. In addition, in contrast to the anti-apoptotic Bcl-2 proteins, BHRF1 does not bind tightly to peptides derived from the pro-apoptotic proteins Bak, Bax, Bik, and Bad. The lack of an exposed, pre-formed binding groove in BHRF1 and the lack of significant binding to peptides derived from pro-apoptotic family members that bind to other anti-apoptotic family members, suggest that the mechanism of the BHRF1 anti-apoptotic activity does not parallel that of cellular Bcl-x(L) or Bcl-2.
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(as it appears on PubMed at http://www.pubmed.gov), where 14499614 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14499614}}
==About this Structure==
==About this Structure==
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1Q59 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q59 OCA].
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1Q59 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q59 OCA].
==Reference==
==Reference==
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[[Category: Nmr spectroscopy]]
[[Category: Nmr spectroscopy]]
[[Category: Structure determination]]
[[Category: Structure determination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:52:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:43:53 2008''

Revision as of 03:43, 28 July 2008

Image:1q59.png

Template:STRUCTURE 1q59

Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2

Template:ABSTRACT PUBMED 14499614

About this Structure

1Q59 is a Single protein structure of sequence from Human herpesvirus 4. Full experimental information is available from OCA.

Reference

Solution structure of the BHRF1 protein from Epstein-Barr virus, a homolog of human Bcl-2., Huang Q, Petros AM, Virgin HW, Fesik SW, Olejniczak ET, J Mol Biol. 2003 Oct 3;332(5):1123-30. PMID:14499614

Page seeded by OCA on Mon Jul 28 06:43:53 2008

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