1nuh

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{{STRUCTURE_1nuh| PDB=1nuh | SCENE= }}
{{STRUCTURE_1nuh| PDB=1nuh | SCENE= }}
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'''The crystal structure of human phosphoglucose isomerase complexed with 5-phosphoarabinonate'''
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===The crystal structure of human phosphoglucose isomerase complexed with 5-phosphoarabinonate===
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==Overview==
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Phosphoglucose isomerase (PGI) is a workhorse enzyme of carbohydrate metabolism that interconverts glucose 6-phosphate and fructose 6-phosphate. Outside the cell, however, the protein appears to function as a cytokine. A crystal structure of human PGI bound with 5-phosphoarabinonate, a strong inhibitor that mimics the cis-enediol(ate) intermediate of the reaction, has been determined at 2.5 A resolution. The structure helps to confirm the assignment of Glu357 as the base catalyst in the isomerase reaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 12777791 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12777791}}
==Disease==
==Disease==
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[[Category: Glycolysis enzyme]]
[[Category: Glycolysis enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:44:20 2008''

Revision as of 03:44, 28 July 2008

Image:1nuh.png

Template:STRUCTURE 1nuh

Contents

The crystal structure of human phosphoglucose isomerase complexed with 5-phosphoarabinonate

Template:ABSTRACT PUBMED 12777791

Disease

Known disease associated with this structure: Hemolytic anemia due to glucosephosphate isomerase deficiency OMIM:[172400], Hydrops fetalis, one form OMIM:[172400]

About this Structure

1NUH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of human phosphoglucose isomerase complexed with a transition-state analogue., Davies C, Muirhead H, Chirgwin J, Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):1111-3. Epub 2003, May 23. PMID:12777791

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