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1s5g

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{{STRUCTURE_1s5g| PDB=1s5g | SCENE= }}
{{STRUCTURE_1s5g| PDB=1s5g | SCENE= }}
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'''Structure of Scallop myosin S1 reveals a novel nucleotide conformation'''
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===Structure of Scallop myosin S1 reveals a novel nucleotide conformation===
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==Overview==
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Structural studies of myosin have indicated some of the conformational changes that occur in this protein during the contractile cycle, and we have now observed a conformational change in a bound nucleotide as well. The 3.1-A x-ray structure of the scallop myosin head domain (subfragment 1) in the ADP-bound near-rigor state (lever arm =45 degrees to the helical actin axis) shows the diphosphate moiety positioned on the surface of the nucleotide-binding pocket, rather than deep within it as had been observed previously. This conformation strongly suggests a specific mode of entry and exit of the nucleotide from the nucleotide-binding pocket through the so-called "front door." In addition, using a variety of scallop structures, including a relatively high-resolution 2.75-A nucleotide-free near-rigor structure, we have identified a conserved complex salt bridge connecting the 50-kDa upper and N-terminal subdomains. This salt bridge is present only in crystal structures of muscle myosin isoforms that exhibit a strong reciprocal relationship (also known as coupling) between actin and nucleotide affinity.
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(as it appears on PubMed at http://www.pubmed.gov), where 15184651 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15184651}}
==About this Structure==
==About this Structure==
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[[Category: Novel conformation of nucleotide]]
[[Category: Novel conformation of nucleotide]]
[[Category: Scallop myosin s1]]
[[Category: Scallop myosin s1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:19:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:46:39 2008''

Revision as of 03:46, 28 July 2008

Image:1s5g.png

Template:STRUCTURE 1s5g

Structure of Scallop myosin S1 reveals a novel nucleotide conformation

Template:ABSTRACT PUBMED 15184651

About this Structure

1S5G is a Protein complex structure of sequences from Argopecten irradians. Full crystallographic information is available from OCA.

Reference

Myosin subfragment 1 structures reveal a partially bound nucleotide and a complex salt bridge that helps couple nucleotide and actin binding., Risal D, Gourinath S, Himmel DM, Szent-Gyorgyi AG, Cohen C, Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8930-5. Epub 2004 Jun 7. PMID:15184651

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